About Me

I work in the Genome Institute at Washington University in St. Louis, where I lead a group that develops and applies computational tools to give us insight into the origins and progression of cancer.

My core research interests include:

  • Cancer - studying the genomic alterations that result in tumorigenesis
  • The clonal architecture of tumors and how they evolve in response to therapy
  • Integrative analysis to place genomic aberrations into a functional context
  • Effective design and targeting of cancer immunotherapies
  • Developing open-source software for integrating, mining, and visualizing genomic data
  • Utilizing online technologies to drive science communication and collaboration

  • Education


    Publications


    * denotes shared first authorship

    Presentations

    • Characterizing genomic responses to cancer immunotherapy
      Genome Informatics (2016)
    • Genomic insights into tumor evolution and therapy response
      Festival of Genomics Boston (2016)
    • Assessing tumor heterogeneity and tracking clonal clearance in response to therapy
      Genome Informatics (2015)
    • Ultra-deep whole-genome sequencing reveals clinically relevant low-frequency subclones in an acute myeloid leukemia
      The Cancer Genome Atlas Symposium (2014)
    • SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution and therapy resistance
      Personal Genomes & Pharmacogenomics (2013)
    • Multi-dimensional clustering of mutations from heterogeneous tumors offers insight into clonal architecture, tumor evolution, and response to therapy
      The Cancer Genome Atlas Steering Committee Meeting (2013)
    • Assessing Tumor Heterogeneity and Tracking Clonal Evolution Using Whole Genome or Exome Sequencing
      The Cancer Genome Atlas Scientific Symposium (2012) link
    • An Image Analytic Approach to Characterizing Vasculogenic Networks
      Presentation: Truman State University Student Research Symposium (2005)

    Teaching

    • Guest Lecture - Investigating Eukaryotic Genomes (2016)
    • Guest Lecture - Investigating Eukaryotic Genomes (2015)
    • Guest Lecture - Molecular Basis of Heredity (2015)
    • Computer Aided Discovery Methods (2007 and 2008)
      Contributed to the development of the course and taught computational labs on:
      • Studies of genome variation
      • Transcriptional regulatory pathways
    • Computational Mathematics for Biomedical Scientists (2008)
      • Teaching Assistant
    • Advanced Topics: Quantitative Biology (2005)
      • Teaching Assistant

    Editorial

    Ad-hoc reviewer for Bioinformatics, Cancer Cell, Genome Biology, PLoS Computational Biology, Nucleic Acids Research.
    Grant reviewer for Dutch Cancer Society (KWF Kankerbestrijding)

    Other

    • I write about the intersection of science, technology, and culture at http://www.chrisamiller.com/science/
    • BCM Graduate Student Council
         - Vice-president 2008
         - SCBMB representative 2007
    • Member of Phi Sigma Pi National Honor Fraternity
         - Chapter Service Key recipient (2004)
    • Eagle Scout